CENP (Centromere protein) 抑制因子

The centromere protein family (CENP) is a group of proteins that are fundamentally important in the proper segregation of chromosomes during cell division. These proteins localize to the centromere, the part of the chromosome that is responsible for directing the movement of chromosomes to opposite ends of the dividing cell. They are involved in the formation of the kinetochore, a complex protein structure on the chromosome where spindle fibers attach during mitosis or meiosis. CENP signaling is critical for the kinetochore-microtubule attachment, ensuring that genetic material is accurately distributed to daughter cells. Any disruptions in the function of CENPs can lead to chromosomal instability, which is a hallmark of many forms of aneuploidy and is often associated with various issues..

Centromere protein (CENP) inhibitors are specialized molecules that target and hinder the activity of centromere proteins, which are essential components of the cell's machinery for accurate chromosome segregation during cell division. The centromere is a specialized region of the chromosome that plays a key role in chromosomal dynamics during mitosis and meiosis, and it is here that CENP molecules exert their function. The inhibitors in this class are designed to bind to specific CENP proteins, such as CENP-A, CENP-B, and CENP-C, among others, each of which has a distinct role in the structural and functional assembly of the kinetochore complex.