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Estrutura molecular do Disulfiram, Número CAS: 97-77-8
Disulfiram (CAS 97-77-8)
Veja citações de produtos (7)
Nomes alternativos:
Tetraethylthiuram disulfide
Aplicacao:
Disulfiram é um inibidor da ALDH e do crescimento das células tumorais
Numero VAT:
97-77-8
Privada:
≥97%
Peso Molecular:
296.54
Separar por Funcao:
C10H20N2S4
Informação complementar:
Este produto está classificado como um Bem Perigoso para transporte e pode estar sujeito a custos de envio adicionais.
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
LINKS RÁPIDOS
Informacoes sobre ordens
Citacoes dos Produtos
Descricao
Informações Técnicas
Informações de Segurança
SDS & Certificado de Análise
O dissulfiram é um agente desmetilante de DNA e indutor de DIG1 que inibe o crescimento de células de câncer de próstata por meio da inibição da DNA metiltransferase (Dnmt). Além disso, estudos indicam que o dissulfiram inibe a aldeído desidrogenase (ALDH), resultando no acúmulo de acetaldeído após a ingestão de etanol. Estudos alternativos mostram que o dissulfiram também inibe a dopamina beta-hidroxilase (DBH), uma enzima importante na conversão de dopamina em norepinefrina nos neurônios noradrenérgicos. Além disso, o dissulfiram pode reduzir a toxicidade e a carcinogênese ao inibir o citocromo P450IIE1 (CYP2E1). Foi relatado que o dissulfiram também pode inibir o crescimento de células tumorais por meio da ligação ao cobre celular, que inibe a atividade do proteossomo e induz a apoptose. O dissulfiram é um inibidor do ADH e da V-ATPase.
Disulfiram (CAS 97-77-8) Referencias
- Efeitos do dissulfiram no P450IIE1 hepático, noutras enzimas microssomais e na hepatotoxicidade em ratos. | Brady, JF., et al. 1991. Toxicol Appl Pharmacol. 108: 366-73. PMID: 1850173
- O dissulfiram atenua a reativação da procura de cocaína, estimulada pela droga, através da inibição da dopamina β-hidroxilase. | Schroeder, JP., et al. 2010. Neuropsychopharmacology. 35: 2440-9. PMID: 20736996
- O dissulfiram é um agente desmetilante do ADN e inibe o crescimento das células do cancro da próstata. | Lin, J., et al. 2011. Prostate. 71: 333-43. PMID: 20809552
- Um novo análogo de ditiocarbamato com inibição potencialmente reduzida de ALDH tem atividade inibidora do proteassoma dependente de cobre e indutora de apoptose em células humanas de cancro da mama. | Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945
- O dissulfiram, medicamento para o abuso do álcool, tem como alvo o cancro através do adaptador NPL4 da p97 segregase. | Skrott, Z., et al. 2017. Nature. 552: 194-199. PMID: 29211715
- Efeito terapêutico do complexo de inclusão de dissulfiram incorporado em hidroxipropil-β-ciclodextrina em ratos machos portadores de glioma intracraniano por via intranasal. | Qu, Y., et al. 2021. Eur J Pharm Sci. 156: 105590. PMID: 33065226
- O dissulfiram inibe a inflamação e a fibrose num modelo de obstrução ureteral unilateral em ratos através da inibição da clivagem da gasdermina D e da piroptose. | Zhang, Y., et al. 2021. Inflamm Res. 70: 543-552. PMID: 33851234
- Nanopartículas de cobre-dissulfiram sensíveis à glutationa para uma melhor quimioterapia de tumores. | Chen, M., et al. 2022. J Control Release. 341: 351-363. PMID: 34856225
- Reaproveitamento do dissulfiram como sensibilizador quimioterapêutico: Alvos moleculares e mecanismos. | Sun, F., et al. 2022. Anticancer Agents Med Chem. 22: 2920-2926. PMID: 35430981
- O dissulfiram reforça a imunidade anti-tumoral das células T através da ativação direta da sinalização TCR mediada por LCK. | Wang, Q., et al. 2022. EMBO J. 41: e110636. PMID: 35638332
- Cu(II) em estilo buffet para melhorar a terapia do cancro à base de dissulfiram. | Zhao, L., et al. 2022. J Colloid Interface Sci. 624: 734-746. PMID: 35696791
- A viagem do dissulfiram desde a vulcanização da borracha até à ativação das células T. | Dosset, M. and Zanetti, M. 2022. EMBO J. 41: e111862. PMID: 35848116
- Os análogos do dissulfiram e do ditiocarbamato demonstram efeitos anti-esquistossomóticos promissores. | Rennar, GA., et al. 2022. Eur J Med Chem. 242: 114641. PMID: 36027862
- Nanopartículas de fosfato de cálcio carregadas com dissulfiram para uma melhor imunoterapia contra o cancro. | Li, Q., et al. 2022. Biomaterials. 291: 121880. PMID: 36334355
- O dissulfiram acelera a cicatrização das úlceras do pé diabético bloqueando a formação de NET através da supressão da via NLRP3/Caspase-1/GSDMD. | Yang, S., et al. 2023. Transl Res. 254: 115-127. PMID: 36336332
Inibidor de:
αC-crystallin, β-defensin 134, β-defensin 136, γ-crystallin, 1300002K09Rik, 17β-HSD8, 1700055N04Rik, 2310079F23Rik, 2610110G12Rik, 2700081O15Rik, 2810408P10Rik, 2810422O20Rik, 2810474O19Rik, 2900024O10Rik, 4833422F24Rik, 4921521F21Rik, 4930422I07Rik, 4930432O21Rik, 4930435E12Rik, 4930455F23Rik, 4930502E18Rik, 4933422H20Rik, 6430526N21Rik, 7530422B04Rik, A630033E08Rik, Aasdh, ACAD-8, ACTR6, ACY1L2, ADAM4, ADAMTS-13, ADAMTS-L2, ADAR3, Adenovirus hexon protein, Adenovirus-5 hexon, ADH, ADHα, ADHβ, ADH4, ADH5, ADH6A, ADO, AIP4, AKR1C21, AKR1CL2, AKR7A2, AKR7A3, AKR7A4, AKR7A5, Alcohol Dehydrogenase, Aldehyde Dehydrogenase, ALDH, ALDH18A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1A7, ALDH2, ALDH3A2, ALDH3B1, ALDH3B2, ALDH5A1, ALDH6A1, ALDH8A1, ALDH9A1, ALKBH2, ALKBH3, ALS2CL, ANGRP, ANKRD26, ANP32B, APOBEC3B, ARD, ARID3C, Arp, Arylsulfatase F, Arylsulfatase G, Arylsulfatase J, ASB-15, ASMTL, ASRGL1, ASXL1, ASZ1, ATP6E1, ATP7B, AU017455, AUH, Azi2, BAF53B, BAGE, BAGE3, BAT2L, BAT3, BAT4, BAZ1A, BCAT2, BCDIN3, Bcl-11a, BCMO1, BCoR, BCORL1, BCRF1, BMAL2, BPV E2, BRE, BTEB2, C10orf131, C11orf51, C12orf62, C13orf33, C1orf156, C1orf181, C20orf165, C3orf21, C3orf59, C3orf64, C4BPα, C6orf32, C8orf70, C9orf21, C9orf41, CARD 8, CAT-2, cathepsin 7, CBR4, CD133, CD66E, CD92, Cdk11, CEACAM5, CEM15, CGR19, CHDH, CHMP4, Chr-B, CINAP, CMG1, CNG-β3, COA6, COL11A2, COL16A1, COL18A1, COL22A1, COL23A1, COL29A1, COL6A3, COL7A1, COL9A1, Collagen α2 Type VI, Collagen Type IV, COMMD3, COPT2, COUP-TF2, CPXCR1, CPZ, CRABP-I, CRABP-II, CRBP I, CRBP II, CRELD1, CRYZL1, CSN7a, CUTC, CXorf34, CYB561D1, CYB561D2, Cyclophilin D, CYP2B13, CYP2B19, CYP2B23, Cyp2c65, Cyp2c66, Cyp2c69, CYP2E1, Cytokeratin 4, Cytokeratin 5, Cytokeratin 6D, Cytokeratin 6E, Cytokeratin 7, Cytokeratin 9, DACH1, DACH2, DBH, DDO, DDTL, Dexras1, DHDH, DHRS11, DHRS12, DHRS3, DHRS4, DHRS4L2, DHRS7B, DHRS7C, DLG5, Dlx-6, Dnmt, Dnmt1, Dnmt2, Dnmt3a, Doxl2, DPM3, DPP3, DPRX, dsg1β, DUX, DUX4L15, DUXBL, EBV gp220, ECHDC1, EFO1, EG210155, EG628705, EG636741, EG666209, EG666257, EG669998, eIF3δ, EMID1, EMID2, ephrin-A5, ESET, Eso-1, FAM168A, FAM213A, Fcrl5, Fibrillarin-like 1, fibrillin-2, FIV gp36, FIV p27, FLJ42117, Follicular DC Marker, FOXD4L4, FRP1, FRY, FTZ-F1, FucT-IX, GAGE, GAGE12C, GAGE2A, GAGE6, GAGE7B, gasdermin, gasdermin A2, gasdermin A3, gasdermin C, GASP-2, GATC, GEF-H1, GLOD4, GLT8D4, Glutamate Dehydrogenase, Glyoxalase I, GM-CSFR, Gm428, Gm44, Gm648, GNS, GPR42, GPx-4, GPx-7, Grid2, Grx1, Grx5, GSDMC2, GSDMC4, GSTM6, GSTT2B, h-prune, H2-Abβ, H2-Dd, H2-M1, H2afb2, HAGHL, HAH1, Halotyrosine, HAPLN1, HBXIP, hCG_1982709, hCG_40738, HE4, HEM1, HEMK2, HEN1, Hep A, HepaCAM, Herc1, HIBADH, HIC-2, HIGD1C, Histone cluster 1 H1A, Histone cluster 1 H2AA4, Histone cluster 1 H2BP, Histone cluster 1 H3G, Histone cluster 1 H3J, Histone cluster 1 H4I, Histone H2A.F, Histone H2A.J, Histone H3.3A, Histone H3F3C, HIV-1 Tat-SF1, HMG-14, HNF-6, hornerin, HoxA10, HoxA13, HoxA2, HoxA4, HoxA7, HoxA9, HoxB1, HoxB6, HoxC10, HoxC11, HoxC5, HoxD3, HP1α, HP1β, HPA2a, HPV 16-E5, HPV 16-L1, HRCT1, HRG-β, hRIF, HSDL1, HSF2BP, HSFY1, HYAL6, IBRDC2, IFN-α9, IGFBP7, IGSF4C, IL-1F7, ILDR2, ILT-5, Inhibin β-C, Integrin αIIIb, IRF-2BP2, IRG1, JMJD1A, JMJD2D, JMJD3, JMJD8, Jumonji, katacalcin, Khdc1b, KIR2DL3, KLHDC6, KLHL1, KLKb9, KRTAP10-4, KRTAP15-1, KRTAP19-6, KRTAP21-1, KRTAP24-1, Krtap28-10, KRTAP4-11, KRTAP4-8, KRTAP6-1, KRTAP6-3, KRTAP8-2, LAGE-2A, Laminin β-1, Laminin γ-2, LAPTM4B, LDOC1L, LEDGF, LGALS9C, LHX8, LIN-28B, LIV-1_SLC39A6, LOC100039794, LOC100039830, LOC100040458, LOC100040491, LOC100040781, LOC100040981, LOC100041179, LOC390245, LOC439994, LOC646817, LOC728957, LOH11CR2A, LPO, LRAT, LRIT3, LSAMP, Ly6G6c, LYSMD3, LYZL2, MAAI, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A5, MAGE-A6, MAGE-B10, MAGE-B17, MAGE-B2, MAGE-B5, MAGE-E1, MAGE-E2, MAGE-G1, MAN2B1, MAP-2A, MASGP-BP, MASL1, MBD3L2, MBD3L2-5, MBD3L3, MBD3L4, MBD3L5, MBD6, MCJ, MCPyV large T-antigen, Mcsp, MECL-1, MeCP2, Mesogenin 1, Metallothionein, Metallothionein 1A, Metallothionein 3, MetAP-1, METT10D, METTL12, METTL22, METTL9, MFAP1A, MGST1, MGST2, MGST3, MHC Ts H-2s,f, MILI, Mill1, Mill2, MOXD2, MPDZ, MRGX4, MSL3L1, MTF-1, MXRA7, MYBPC3, MYSM1, NAT-16, NAT-9, NBPF1, NCYM, Neurexophilin-1, Neuromedin N, NFYB, NKG2-C, NSP3, NSUN2, NSUN5, NSUN5B, Obp1b, Olfr44, Olfr792, Olfr794, Olfr798, Olfr976, OPN1LW, OPN1MW2, OR2L5, OR52A1, OS-9, OTTMUSG00000010552, OXNAD1, P42pop, p73α, PA200, PAAF1, PADI1, PADI2, PADI3, PADI6, PARD6B, PARP-6, PCDH10_Pcdh10, PCDHA1, PCDHA12, PCDHA2, PCDHA3, PCDHAC2_Pcdhac2, PCDHGA1, PCDHGA12, PCDHGA5, PCDHGA6, PCDHGA9, PCDHGB3, PCDHGB5, PCLN-1, PCMT1, PCMTD1, PCPE-2, PDI1 ER e Nuclear Envelope Marker, PHF2, PHYH, PIH1D2, PINX1, PIWIL1, PLAC1L, PLAC8, PLAGL1, plasminogen, PML, Polyoma virus VP1, POU6F2, PRAME like-1, PRAME like-4, PRAME like-5, PRAMEF1, PRAMEF17, PRAMEF18, PRAMEF2, PRAMEF23, PRAMEF24, PRAMEF25, PRAMEF3, PRAMEF4, PRAMEF5, PRAMEF9, PRDM3, PRDM7, PRDM9, Prdx6b, PREP-1, Procollagen Type I, PRODH2, Prominin 2, Protamine 3, PRX IV, PRX1, PRX2, PSG8, PSME proteasome activator subunits (PA28), PWWP2A, pyridoxal kinase, QDPR, Rad54, RAI15, RAI2, RASSF1A, RASSF1B, RASSF1C, RASSF1D, RASSF1E, RASSF1F, RBMY1A1, RBP2, RDH1, RDH10, RDH11, RDH12, RDH14, RDH16, RDH19, RDH9, Renalase, Reprimo, reticulocalbin-2, RFRP, Rhox3c, RNF5, RNMTL1, rotavirus C vp4, rotavirus NSP4, rotavirus vp7, RPE, Rpn2, Rsl2, Rslcan-10, Rslcan-13, Rslcan-14, Rslcan-2, Rslcan-23, Rslcan-5, Rslcan-6, Rslcan-7, Ruvbl2, S-100A16, sarcosine dehydrogenase, SATB2, SCCRO, SCMH1, SCML1, SDR16C6, Selenoprotein K, Selenoprotein O, Selenoprotein R, Selenoprotein V, SEP15, Septin 1, SerpinB1a, Serpinb3a, Serpinb3b, SET8, SETD2, SETMAR, SFMBT2, Sialosyl Lewis a, Siglec-L1, Six6, Smarcad1, SMCHD1, SMYD1, SMYD2, SNARK, SOHLH2, SorCS3, SPANX-5, SPANX-A, SPOPL, SPR-5, SPTRX-3, SSX2, SSX2-IP, STEAP, SUZ12, Syntaxin 1A, SYT, TBC1D24, TBX15, Tctex3, TDRD1, Tensin, TET3, TETRAN, Thrombospondin 3, TIF1β, TIP120B, TIS11D, TM6SF2, TMC8, TMEM145, TMTSP, Tomt, TOPAZ1, TPSB2, Trim29, TRIM5α, TRIM79, TRIP15, tropoelastin, TSPY8, TSSC3, TXNDC10, TXNDC14, TZFP, UBA2, UBA3, Ubr3, UFM1, ULBP4, Urm1, URO-10, URO-5, V-ATPase, Vangl2, VpreB3, VWA5B2, VWC2, WDR38, WDR5B, WFIKKN, XAGE-1B, XAGE-3, XAP8, YB-1, ZADH1, ZADH2, ZBED1, ZBTB1, ZBTB25, ZBTB34, ZBTB38, ZBTB40, ZBTB43, ZCCHC12, ZCCHC17, ZDBF2, ZFOC1, ZFP39, ZFP40, ZFP433, ZFP59, ZFP61, Zfp663, ZFP712, ZFP719, Zfp871, ZFP94, ZIM1, ZIM2, ZIM3, ZIP1, ZMAT1, ZMAT2, ZMYM3, ZNF12, ZNF142, ZNF191, ZNF205, ZNF206, ZNF21, ZNF222, ZNF232, ZNF256, ZNF258, ZNF263, ZNF295, ZNF313, ZNF336, ZNF35, ZNF354A, ZNF397, ZNF397OS, ZNF407, ZNF434, ZNF442, ZNF446, ZNF449, ZNF497, ZNF499, ZNF518B, ZNF552, ZNF555, ZNF576, ZNF577, ZNF580, ZNF581, ZNF589, ZNF596, ZNF6, ZNF610, ZNF618, ZNF625, ZNF629, ZNF644, ZNF645, ZNF646, ZNF654, ZNF673, ZNF682, ZNF688, ZNF701, ZNF708, ZNF717, ZNF720, ZNF730, ZNF74, ZNF75A, ZNF77, ZNF780B, ZNF792, ZNF800, ZNF808, ZNF831, ZNF843, ZNF85, ZNF853, ZnT-1, ZPI, ZPLD1, ZSCAN4C, Zwilch, e ZXDB.Ativado de:
1700055N04Rik, 20S Proteasome α5, 20S Proteasome β1, 2610029I01Rik, 2610305D13Rik, 26S Proteasome p54, 2700081O15Rik, 2810408P10Rik, 3 BP-1, 3830417A13Rik, 4933402E13Rik, 4933422H20Rik, Ada2, ADAT1, Adenovirus-5 hexon, ADH8, Aldehyde Dehydrogenase, ALDH1B1, ALDH3A1, ALDH3B1, APOBEC3A, APOBEC3C APOBEC3D, APOBEC3G, ARID3B, ATP7A, ATXN3L, BAGE3, BAZ2A, BS69, BTBD11, BTBD8, C1orf105, C1orf112, C1orf94, C3orf33, C4orf30, C9orf142, CCDC21, CCDC76, Centaurin β5, CGBP, CHAC1, COMMD10, COMMD4, COMMD7, COMMD8, COMMD9, COX17, COX19, CRABP-II, CSS2, CT45-1, CTR1, Cup1, CUTC, CYP26A1, DAZAP1, dcTRAILR2, Dcun1D4, DFNA5, Dimethyl Histone H3, DnaJB5, DOHH, E(z), E6-AP, EBV Bam HI Z, EBV gp220, EBV ZEBRA, ECOP, EED, EG669998, EGL-27, eIF3ε, ERVK6, FAM188B2, FAM208A, FBL10, FBL11, FBXO4, FBXO8, FILIP1L, FIV gp36, FIV p27, FLYWCH1, FMR2, FRBZ1, FXR1, GAGE10, GAGE12C, GAGE13, GAGE7B, GATAD2A, GDF5OS, Gm1862, Gm514, GSTP1, H2-M10.2, H2-M10.5, H2-M11, H2-M9, H2-T24, H2AL1, H2BFWT, HEPHL1, HHV-6, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AF, Histone cluster 1 H2AL, Histone cluster 1 H2BA, Histone cluster 1 H2BE, Histone cluster 1 H2BG, Histone cluster 1 H2BL, Histone cluster 1 H3A, Histone cluster 1 H3G, Histone cluster 1 H3I, Histone cluster 1 H4H, Histone cluster 1 H4J, Histone cluster 2 H2AB, Histone cluster 2 H3D, Histone cluster 2 H4A, Histone H10, Histone H2B.S, Histone H2BM, HIV gp24, HIV-1 Gag, HIV-1 p17, HIV-1 p55, HIV-1 Rev, HIV-1 Tat, HIV-1 Vif, HIV-2 gp39, HKDC1, HL60 Antigen, HLA-A2, HMG-1L, HoxD8, HSPC038, HTLV-1 gp46, HTLV-1 p24, HTR3E, IDH1, IL-5R, ING4, ING5, INTS3, JMJD2C, Khdc1b, KIAA1305, KK-LC-1, KLHL4, KRBOX1, KSHV ORF 45, LAGE-2A, LDOC1, LINE-1, LOC100039269, LOC100040870, LOC100041107, LOC100041179, LOC100041230, LOC100041244, LOC100041254, LOC100041407, LOC145837, LOC150383_2210021J22Rik, LOC283547, LOC439950, LOC439994, LOC643749, LOC644135, LOC644248, LOC645359, LOC646522, LOC646719, LOC729454, LUCA15, Mac-2BP, MafK, MAGE, MAGE-A5, MAGE-C2, MAGE-D4, MAGE-D4B, MAGE-F1, MBD3L2, MBD3L4, MBD6, MBTD1, MGST3, MICA, MLL, MOV10L1, MOXD1, MOXD2, Mucin 16, N28178, NBPF24, NBPF3, NESP55, NKp46, NUDT7, OR10K1, OR2G2, OR5H15, p73α, PAGE-5, PAM, PATL1, PC4, PCAN1, PCDHB1, PCDHB2, PCGF1, PCNP, PDRG, PGBD2, PHC1, PHF20, PHF20L1, PHF7, Polycomb, PPIAL4G, PRAME like-3, PRAME like-5, PRAME like-6, PRAME like-7, PRAMEF1, PRAMEF10, PRAMEF12, PRAMEF13, PRAMEF15, PRAMEF16, PRAMEF18, PRAMEF20, PRAMEF23, PRAMEF4, PRDM5, Prdx6b, PROS-30, PRPF38B, PRRT3, PSMB11, PSMB4, PUSL1, R3HDM2, RASSF1A, RASSF1B, RASSF1E, RASSF1F, RBA-1, Rhodanese, RING1B, RNase HII-B, RSRC1, RWDD2B, S-100A13, SART-3, SBZF3, SCAND1, SCO1, Selenoprotein I, Selenoprotein W, SerpinA2, SFMBT1, Slfn, SmcX, SMF_Hmgxb3, SorCS3, Sox-22, SP140, SPF30, Spi13, SSX1, stefin A1, stefin A2, SUHW1, SUV39H1, TADA2L, TDRD5, TDRKH, TESSP5, THAP10, TIGD4, TIGD5, TRIM5, TRIM6, Trimethyl Histone H4, TXNDC10, TXNDC15, TXNDC16, TXNDC9, UBCH10, UBE2CBP, UBE2O, UHRF1, USP22, USP28, USP45, UTY, vCCI, VSIG8, WDR21A, WDR52, WHIP, WSB2, XAGE-1, XAGE-1B, YY1AP1, ZBBX_FLJ23049, ZBTB37, ZCWPW2, ZFP1, ZFP14, ZFP287, Zfp738, ZFP772, Zfp93, ZMYND12, ZMYND15, ZNF14, ZNF213, ZNF214, ZNF279, ZNF382, ZNF385A, ZNF452, ZNF500, ZNF620, ZNF622, ZNF625, ZNF646, ZNF670, ZNF70, ZNF704, ZNF740, ZNF75A, ZNF778, ZNF780B, ZNHIT6, ZnT-10, ZnT-7, e ZSWIM6.Informacoes sobre ordens
| Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
Disulfiram, 50 g | sc-205654 | 50 g | RMB587.00 | |||
Disulfiram, 100 g | sc-205654A | 100 g | RMB982.00 |