ZNF202 抗体 (GG-7): sc-101074

ZNF202 Antibody (GG-7) is an IgG_2a κ mouse monoclonal ZNF202 antibody (also designated ZNF202 antibody) that detects the ZNF202 protein of human origin by WB, IP, IF, IHC(P) and ELISA. ZNF202 Antibody (GG-7) is available as the non-conjugated anti-ZNF202 antibody. Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF202 (zinc finger protein 202), also known as ZKSCAN10, is a 648 amino acid protein that contains eight C2H2-type zinc fingers, one KRAB domain and one SCAN box domain. Localized to the nucleus and expressed at high levels in the testis, ZNF202 belongs to the Krüppel C2H2-type zinc-finger protein family and functions as a transcriptional repressor of genes that are involved in lipid metabolism. ZNF202 regulates the expression of several classes of proteins, including lipoprotein particles, transporters involved in lipid homeostasis, enzymes involved in lipid processing and a wide variety of proteins that are associated with energy metabolism. Defects in the gene encoding ZNF202 are associated with high cholesterol and may be involved in the pathogenesis of lung, ovarian and breast cancer. Two isoforms of ZNF202, designated alpha and beta, exist due to alternative splicing events.

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References:

1. A broad role for the zinc finger protein ZNF202 in human lipid metabolism.  |  Wagner, S., et al. 2000. J Biol Chem. 275: 15685-90. PMID: 10748193
2. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.  |  Porsch-Ozcurumez, M., et al. 2001. J Biol Chem. 276: 12427-33. PMID: 11279031
3. Cross talk of two Krupple transcription factors regulates expression of the ovine FSH receptor gene.  |  Xing, W. and Sairam, MR. 2002. Biochem Biophys Res Commun. 295: 1096-101. PMID: 12135607
4. ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation.  |  Langmann, T., et al. 2003. J Lipid Res. 44: 968-77. PMID: 12611910
5. Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism.  |  Schmitz, G., et al. 2004. Curr Opin Lipidol. 15: 199-208. PMID: 15017363
6. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study.  |  Stene, MC., et al. 2006. Atherosclerosis. 188: 43-50. PMID: 16289551
7. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.  |  Park, JW., et al. 2006. J Med Genet. 43: 598-608. PMID: 16415175
8. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population.  |  Stene, MC., et al. 2006. J Lipid Res. 47: 944-52. PMID: 16467280
9. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins.  |  Monaco, C., et al. 1998. Genomics. 52: 358-62. PMID: 9790754