Zic3 抗体 (SQ-15): sc-101201

Zic3 Antibody (SQ-15) is an IgG_2a κ mouse monoclonal Zic3 antibody (also designated Zic3 antibody) that detects the Zic3 protein of mouse, rat and human origin by WB, IP and ELISA. Zic3 Antibody (SQ-15) is available as the non-conjugated anti-Zic3 antibody. Zic3 (zinc finger protein of the cerebellum 3) is a C2H2 zinc finger transcription factor that establishes a proper left-right axis and midline neural patterning during early development of the vertebrate embryo. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. Zic3 mutations in the zinc finger DNA binding domain and in the N-terminal domain result in loss of reporter gene transactivation, and mutations between amino acids 253-323 of the Zic3 protein causes aberrant cytoplasmic localization rather than the wild type nuclear localization.

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References:

1. Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.  |  Salero, E., et al. 2001. J Biol Chem. 276: 1881-8. PMID: 11038359
2. Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.  |  Ogura, H., et al. 2001. Behav Genet. 31: 317-24. PMID: 11699604
3. Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation.  |  Ebert, PJ., et al. 2003. Development. 130: 1949-59. PMID: 12642498
4. The role of ZIC3 in vertebrate development.  |  Herman, GE. and El-Hodiri, HM. 2002. Cytogenet Genome Res. 99: 229-35. PMID: 12900569
5. Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection.  |  Zhang, J., et al. 2004. Development. 131: 1553-62. PMID: 14985256
6. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.  |  Grinberg, I., et al. 2004. Nat Genet. 36: 1053-5. PMID: 15338008
7. The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.  |  Nagai, T., et al. 1997. Dev Biol. 182: 299-313. PMID: 9070329