Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
Human vaccina-related kinases 1 and 2 (VRK1,2) are NLS-containing, serine/threonine poxvirus-related kinases that are similar to casein kinase-1 family members. These VRK kinases phosphorylate transcription factors related to stress responses, such as p53. As an upstream regulator of p53, VRK-1 is capable of phosphorylating phosvitin, casein, histone 2b and myelin basic protein. VRK1 co-localizes with ATF2 in the nucleus and can form a stable complex. VRK1 phosphorylates ATF2 mainly on Thr 73, stabilizing the ATF2 protein and increasing its intracellular level. VRK1 phosphorylates human p53 in Thr18 and disrupts p53-Mdm2 interaction in vitro. VRK1 phosphorylates c-Jun in Ser 63 and Ser 73 in vitro (the same residues targeted by the N-terminal kinase of c-Jun (JNK)), and activates c-Jun dependent transcription.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | VRK1 | 7443 | 14q32.2 | XM_006720247, XM_011537132, XM_017021622, XM_017021624, XM_017021625, XM_017021626, NM_003384 | Q99986 | 602168 |
Mouse | Vrk1 | 22367 | 12 F1 | XM_006515809, XM_006515810, XM_006515811, XM_006515812, XM_011244103, XM_011244104, XM_017315045, XM_017315046, XM_017315047, NM_001029843, NM_001029844, NM_011705 | Q80X41 | N/A |