VRK1 抗体 (1F6): sc-101554

Human vaccina-related kinases 1 and 2 (VRK1,2) are NLS-containing, serine/threonine poxvirus-related kinases that are similar to casein kinase-1 family members. These VRK kinases phosphorylate transcription factors related to stress responses, such as p53. As an upstream regulator of p53, VRK-1 is capable of phosphorylating phosvitin, casein, histone 2b and myelin basic protein. VRK1 co-localizes with ATF2 in the nucleus and can form a stable complex. VRK1 phosphorylates ATF2 mainly on Thr 73, stabilizing the ATF2 protein and increasing its intracellular level. VRK1 phosphorylates human p53 in Thr18 and disrupts p53-Mdm2 interaction in vitro. VRK1 phosphorylates c-Jun in Ser 63 and Ser 73 in vitro (the same residues targeted by the N-terminal kinase of c-Jun (JNK)), and activates c-Jun dependent transcription.