VPS11 抗体 (S-38): sc-100893

Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. VPS11 (vacuolar protein sorting 11), also known as END1, PEP5, RNF108 or PP3476, localizes to the membrane of both the endosome and the lysosome and is the human homolog of yeast Vsp11. Expressed ubiquitously with highest expression in heart, VPS11 is thought to play a role in vesicle-mediated protein trafficking, as well as fusion/docking reactions in late endosomes and lysosomes. VPS11 contains one clathrin repeat and one RING-type zinc finger and shares 24% amino acid identity with its yeast counterpart.