USP48 抗体 (5C2): sc-100635

USP48 Antibody (5C2) is an IgG₁ κ mouse monoclonal USP48 antibody that detects the USP48 protein of human origin by WB, IP, IF, IHC(P) and ELISA. USP48 Antibody (5C2) is available as the non-conjugated anti-USP48 antibody. The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP48 (ubiquitin specific peptidase 48), also known as USP31 or RAP1GA1 is a widely expressed 1,035 amino acid protein that belongs to the peptidase C19 family of proteins. Containing three DUSP domains and one ubiquitin-like domain, USP48 functions as a deubiquitinating enzyme that cleaves ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. By reversing the ubiquitination of proteins such as TRAF2 and TRAF6, USP48 plays an important role in the regulation of NFκB activation. Seven isoforms of USP48 are expressed due to alternative splicing events.

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References:

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