UNC45A 抗体 (AbS1): sc-101493

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- UNC45A 抗体 AbS1 是小鼠单克隆 IgG_2b κ，UNC45A抗体, 在1篇文献中引用，规格为200 µg/ml
- 免疫human物种的UNC45A
- UNC45A 抗体 (AbS1) 推荐用于 WB, IP 和 IF，检测mouse, rat 和human 来源的 UNC45A
- 抗-UNC45A 抗体 (AbS1) 可偶联 琼脂糖 用于 IP; HRP 用于 WB, IHC(P) 和 ELISA; 还可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM
- 还可偶联Alexa Fluor^® 488, Alexa Fluor^® 546, Alexa Fluor^® 594 和 Alexa Fluor^® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
- 还可偶联Alexa Fluor^® 680 和 Alexa Fluor^® 790，用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR^®/Odyssey^®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
- 关于如何获取UNC45A (AbS1): sc-101493的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
- m-IgG_2b BP-HRP 是UNC45A Antibody (AbS1) for WB首选应用二抗. 这些试剂现在以套装形式提供UNC45A Antibody (AbS1) (见下方订购信息).

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UNC45 抗体
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UNC45A Antibody (AbS1) is an IgG_2b κ mouse monoclonal UNC45A antibody (also designated UNC45A antibody) that detects the UNC45A protein of mouse, rat and human origin by WB, IP and IF. UNC45A Antibody (AbS1) is available as both the non-conjugated anti-UNC45A antibody form, as well as multiple conjugated forms of anti-UNC45A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. UNC45A (unc-45 homolog A), also known as SMAP1 (Smooth muscle cell-associated protein 1) or GCUNC45, is a 944 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains three TPR repeats. Expressed in spinal cord, bone marrow, peripheral blood leukocytes, trachea, stomach and adrenal gland, UNCA45A functions as a chaperone for HSP 90, effectively facilitating the association of HSP 90 with PR (progesterone receptor). Additionally, UNC45A is thought to be necessary for proper folding of Myosin and is required for normal myotube formation during muscle cell development, thereby playing an important role in muscle formation. Overexpression of UNC45A is associated with rapid cell proliferation and motility, especially that observed in ovarian cancer, suggesting a role for UNC45A in tumorigenesis. Multiple isoforms of UNC45A exist due to alternative splicing events.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. | Price, MG., et al. 2002. J Cell Sci. 115: 4013-23. PMID: 12356907
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. | Chadli, A., et al. 2006. Mol Cell Biol. 26: 1722-30. PMID: 16478993
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. | Bazzaro, M., et al. 2007. Am J Pathol. 171: 1640-9. PMID: 17872978
Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition. | Chadli, A., et al. 2008. Biochemistry. 47: 2850-7. PMID: 18211007
GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. | Chadli, A., et al. 2008. J Biol Chem. 283: 9509-12. PMID: 18285346
Unc45 activates Hsp90-dependent folding of the myosin motor domain. | Liu, L., et al. 2008. J Biol Chem. 283: 13185-93. PMID: 18326487
Loss of unc45a precipitates arteriovenous shunting in the aortic arches. | Anderson, MJ., et al. 2008. Dev Biol. 318: 258-67. PMID: 18462713

种属	基因名称	基因ID	染色质位置	亚型（mRNA）即位号码	蛋白质即位号码	OMIM™ 号码
Human	UNC45A	Entrez Gene ID: 55898	15q26.1	XM_005254963, XM_011521779, XM_011521780, XM_017022407, NM_017979, NM_001039675, NM_001323619, NM_001323620, NM_001323621, NM_018671	UniProt ID: Q9H3U1	611219

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针对哺乳动物和非哺乳动物蛋白靶点的单克隆抗体基本上代表了多克隆抗体覆盖的所有靶点。我们提供超过8300种ImmunoCruz^®偶联抗体，从而可以省去使用二抗。

圣克鲁斯生物技术的抗体有超过36万的研究引文。抗UNC45A抗体(AbS1)在各种科学出版物中有1篇引文。

针对哺乳动物靶标蛋白的一抗，如抗UNC45A 抗体 (AbS1)，推荐用于检测一系列哺乳动物物种，主要有小鼠，大鼠和人物种。许多哺乳动物抗体也非常适合兽医研究，与羊、猪、羊、猫、犬、牛和马的蛋白靶点反应。圣克鲁斯生物技术的单克隆一抗适用于实验室研究应用，不用于诊断或治疗。

UNC45A 抗体 (AbS1) Specifications

替代产品名称

UNC45A

产品克隆名称

AbS1

分类

一抗

Clonality

单克隆抗体

抗体同型

IgG_2b kappa light chain

氨基酸

抗原表位靶标

UNC45A

抗原表位种属

human

产品反应性/检测

UNC45A

种属反应性/检测

mouse, rat, human

其它哺乳动物反应性

N/A

其它非哺乳动物反应性

N/A

应用

WB, IP, IF

瓶的信息

Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

研究引文

1篇各种科学出版物的引文

可选的偶联物/形式

AC: Agarose AF488: Alexa Fluor^® 488 AF546: Alexa Fluor^® 546 AF594: Alexa Fluor^® 594 AF647: Alexa Fluor^® 647 AF680: Alexa Fluor^® 680 AF790: Alexa Fluor^® 790 FITC: Fluoroscein HRP: Horseradish Peroxidase PE: Phycoerythrin

果蝇

非洲爪蟾蜍

拟南芥

秀丽隐杆线虫

梭菌

弯曲杆菌

幽门螺杆菌

肝炎

克雷白氏杆菌

结核分支杆菌

疟原虫

假单胞菌

酿酒酵母

沙门氏菌

血吸虫

志贺氏杆菌

葡萄球菌

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with UNC45A (AbS1): sc-101493?

Asked by: AbPolly

We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety

Answered by: Technical Support

Date published: 2017-02-27

Rated 5 out of 5 by SCBT QC Lab from Good for Western Blot Antibody works for Western blot with UNC45A transfected HEK293T cell lysates in published research. -SCBT QC

Date published: 2023-09-14

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UNC45A 抗体 (AbS1): sc-101493

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References:

UNC45A 抗体 (AbS1) Specifications

替代产品名称

产品克隆名称

分类

Clonality

抗体同型

氨基酸

抗原表位靶标

抗原表位种属

产品反应性/检测

种属反应性/检测

其它哺乳动物反应性

其它非哺乳动物反应性

应用

瓶的信息

研究引文

推荐的二抗检测试剂

可选的偶联物/形式

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with UNC45A (AbS1): sc-101493?