UBE2D2 抗体 (Y-20): sc-100617

UBE2D2 Antibody (Y-20) is an IgG_2a κ mouse monoclonal UBE2D2 antibody (also designated UBE2D2 antibody) suitable for the detection of the UBE2D2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. UBE2D2 Antibody (Y-20) is available as the non-conjugated anti-UBE2D2 antibody. Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53% homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12, in order to conjugate to substrates directed to different proteolytic systems. UBE2D2 catalyzes ubiquitination of IkBa in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component UBE2D2, and UBE2D2 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IkBa for degradation by a proteasome thus lifting the inhibitory effect of IkBa on NFkB and allowing NFkB to enter the nucleus.

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References:

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