TSSK 2 抗体 (S-09): sc-100437

TSSK 2 Antibody (S-09) is an IgG₁ mouse monoclonal TSSK 2 antibody (also designated TSSK 2 antibody) that detects the TSSK 2 protein of human origin by WB, IP, IF, IHC(P) and ELISA. TSSK 2 Antibody (S-09) is available as the non-conjugated anti-TSSK 2 antibody. TSSK 2 (testis-specific serine kinase 2), also known as DGS-G (DiGeorge syndrome protein G), SPOGA2 or STK22B (serine/threonine-protein kinase 22B), is a testis-specific serine/threonine kinase that belongs to the CAMK serine/threonine-protein kinase family. Localizing to the cytoplasm, TSSK 2 contains one protein kinase domain and is believed to play a role in the late stages of spermatogenesis. TSSK 2 shares 83% amino acid identity with the related protein kinase TSSK 1. Specifically, TSSK 2 uses magnesium as a cofactor and catalyzes the transfer of a phosphate from ATP to a target protein, such as SPAG16. Loss of TSSK 2 due to chromosomal deletion has been implicated in velocardiofacial/DiGeorge syndrome (VCFS/DGS), a disorder of development that is characterized by palate anomalies, facial anomalies, immunodeficiency, conotruncal cardiac malformations and hypocalcemia.

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References:

1. A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice.  |  Zuercher, G., et al. 2000. Mech Dev. 93: 175-7. PMID: 10781952
2. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.  |  Hao, Z., et al. 2004. Mol Hum Reprod. 10: 433-44. PMID: 15044604
3. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.  |  Xu, B., et al. 2007. Soc Reprod Fertil Suppl. 63: 87-101. PMID: 17566264
4. Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2.  |  Zhang, Z., et al. 2008. Biol Reprod. 79: 75-83. PMID: 18367677
5. DAZL binds to the transcripts of several Tssk genes in germ cells.  |  Zeng, M., et al. 2008. BMB Rep. 41: 300-4. PMID: 18452650
6. A novel family of serine/threonine kinases participating in spermiogenesis.  |  Kueng, P., et al. 1997. J Cell Biol. 139: 1851-9. PMID: 9412477