Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TRC8 (translocation in renal carcinoma on chromosome 8), also known as RNF139 (ring finger protein 139), RCA1 or HRCA1 (hereditary renal cancer associated 1), is a multi-pass membrane protein that is predominantly expressed in testis, adrenal gland and placenta and is expressed at lower levels in liver, skeletal muscle, pancreas, kidney, brain, heart and lung. Localizing to the endoplasmic reticulum (ER), TRC8 contains ten transmembrane segments, a sterol-sensing domain and one RING-type zinc finger and may function as a ubiquitin ligase and signaling receptor. TRC8 physically interacts with VHL (Von Hippel Lindau disease tumor suppressor), and the inhibition of either of these proteins leads to the same ventral midline defect. Disruption of the TRC8 gene, caused by the 3;8 chromosomal translocation, is associated with hereditary renal cell carcinoma (RCC), suggesting that TRC8 is a potential tumor suppressor for RCC. Further supporting its role as a tumor suppressor, TRC8 mediates the induction of G2/M phase arrest, increased apoptosis and decreased DNA synthesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-101115: TRC8 (YB-16) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: TinTin
Thank you for your question. Yes, sc-101115: TRC8 (YB-16) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 3 out of
Produced acceptable immunoperoxidase membraneProduced acceptable immunoperoxidase membrane and cytoplasmic staining in formalin-fixed, paraffin-embedded human tonsil tissue. -SCBT QC