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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TOPORS Antibody (Y-30) is a high quality monoclonal TOPORS antibody (also designated TOPORS antibody) suitable for the detection of the TOPORS protein of human origin. TOPORS Antibody (Y-30) is available as the non-conjugated anti-TOPORS antibody. TOPORS (topoisomerase I binding, arginine/serine-rich), also known as LUN, RP31, P53BP3 or TP53BPL, is a 1,045 amino acid protein that contains one RING-type zinc finger and localizes to discrete nuclear foci. Expressed in a variety of tissues with highest expression in testis, TOPORS functions as a ubiquitin E3 ligase that, via its RING domain, can ubiquitinate proteins such as p53, thereby targeting them for proteasomal degradation. TOPORS expression can be induced by genotoxic agents (compounds that damage DNA), such as camptothecin and cisplatin, suggesting an important role for TOPORS in DNA damage repair pathways. In addition, TOPORS levels are decreased in lung and colon cancers, implicating TOPORS as a possible tumor suppressor. Defects in the gene encoding TOPORS are the cause of retinitis pigmentosa type 31 (RP31), a degenerative disease characterized by a loss of peripheral and, eventually, central vision.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-101182: TOPORS (Y-30) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: jenni
Thank you for your question. Yes, sc-101182: TOPORS (Y-30) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 4 out of
WB and IF publishable data with human HEK293WB and IF publishable data with human HEK293 and HeLa - SCBT Publication Review
Date published: 2015-04-28
Rated 4 out of
Great immunoperoxidase nuclear staining inGreat immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human lung, adenosqumous cell carcinoma tissue. -SCBT QC