Tim9A 抗体 (SA-19): sc-101285

Tim9A Antibody (SA-19) is an IgG_2a κ mouse monoclonal Tim9A antibody (also designated Tim9A antibody) suitable for the detection of the Tim9A protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Tim9A Antibody (SA-19) is available as the non-conjugated anti-Tim9A antibody. The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins. The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes. Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity. Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health. Tim9A, which maps to human chromosome 14q21, is localized to the intermembrane space of mitochondria and forms heteromeric complexes with Tim10 and Tim12. One complex contains Tim9 and Tim10, whereas the other complex contains Tim9, Tim10 and Tim12, and associates with Tim22. Tim9B (also designated Fracture Callus 1) is expressed in post-fracture calluses from days 5-10.

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References:

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2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.  |  Bauer, MF., et al. 1999. FEBS Lett. 464: 41-7. PMID: 10611480
3. Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration.  |  Bauer, MF. and Neupert, W. 2001. J Inherit Metab Dis. 24: 166-80. PMID: 11405338
4. Cloning of a novel cDNA expressed during the early stages of fracture healing.  |  Hadjiargyrou, M., et al. 1998. Biochem Biophys Res Commun. 249: 879-84. PMID: 9731230
5. Tim9, a new component of the TIM22.54 translocase in mitochondria.  |  Adam, A., et al. 1999. EMBO J. 18: 313-9. PMID: 9889188
6. The preprotein translocase of the mitochondrial inner membrane: function and evolution.  |  Rassow, J., et al. 1999. J Mol Biol. 286: 105-20. PMID: 9931253