TIF1γ 抗体 (XX-19): sc-101179

TIF1γ Antibody (XX-19) is an IgG₁ κ mouse monoclonal TIF1 gamma antibody (also designated TIF1γ antibody) that detects the TIF1 gamma protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. TIF1γ Antibody (XX-19) is available as the non-conjugated anti-TIF1 gamma antibody. Transcriptional intermediary factor 1-α (TIF1α) mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid, and vitamin D3 receptors. TIF1α localizes to nuclear bodies and is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. TIF1β is also a member of the TRIM family that contains both a Cys/His PHD finger and bromodomain that form a cooperative unit required for transcriptional repression. TIF1β mediates transcriptional control by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors and by binding DNA via its zinc finger. TIF1γ has a similar structure to the previous two TRIM members, though it presents several functional differences. TIF1γ interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGFβ.

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References:

1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.  |  Venturini, L., et al. 1999. Oncogene. 18: 1209-17. PMID: 10022127
2. Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krυppel-associated box protein.  |  Gebelein, B. and Urrutia, R. 2001. Mol Cell Biol. 21: 928-39. PMID: 11154279
3. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.  |  Schultz, DC., et al. 2001. Genes Dev. 15: 428-43. PMID: 11230151
4. A new twist in Smad signaling.  |  Heldin, CH. and Moustakas, A. 2006. Dev Cell. 10: 685-6. PMID: 16740469
5. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.  |  He, W., et al. 2006. Cell. 125: 929-41. PMID: 16751102
6. KAP-1, a novel corepressor for the highly conserved KRAB repression domain.  |  Friedman, JR., et al. 1996. Genes Dev. 10: 2067-78. PMID: 8769649
7. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.  |  Moosmann, P., et al. 1996. Nucleic Acids Res. 24: 4859-67. PMID: 9016654