Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
THTR1 Antibody (R-5) is a high quality monoclonal THTR1 antibody (also designated THTR1 antibody) suitable for the detection of the THTR1 protein of human origin. THTR1 Antibody (R-5) is available as the non-conjugated anti-THTR1 antibody. Humans lack biosynthesis pathways for the micronutrients thiamine and folate, however, regulation of these vitamins is necessary for normal cellular function. The SLC19A gene family products mediate membrane transport of these molecules across the membrane to meet cellular requirements; in particular, two transporter proteins differentially import and export thiamine. In the liver as well as other tissues, THTR1 is responsible for the cellular accumulation, that is the import, of thiamine. Uptake depends on many factors, including sodium levels, pH, saturation of thiamine, presence of structural analogues such as oxythiamin and amprolium, as well as membrane transport inhibitors like amiloride. The gene encoding THTR1, SLC19A2, is regulated by GKLF, NF-1 and SP-1. Mutations of the SLC19A2 gene cause thiamine deficiency disorders such as thiamine-responsive megaloblastic anemia (TRMA) by interfering with either the functionality or intracellular targeting of THTR1.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with THTR1 (R-5): sc-100649 antibody?
Asked by: AbPolly
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.