Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TGFβ RI Antibody (RM0016-3A11) is a high quality monoclonal TGF beta RI antibody (also designated TGFBR1 antibody, transforming growth factor beta receptor 1 antibody, or ALK5 antibody) suitable for the detection of the TGF beta RI protein of mouse origin. TGFβ RI Antibody (RM0016-3A11) is available as the non-conjugated anti-TGF beta RI antibody. A total of three members of the TGFβ family, namely TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the TGFβ receptor type-II (TGFβ RII) with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses, TGFβ RII requires both its kinase activity and its association with a TGFβ-binding protein, designated TGFβ receptor type-1 (TGFβ RI). TGFβ RI is a 503 amino acid single-pass type I membrane protein that is expressed ubiquitously and, with TGFβ RII, functions as a receptor for TGFβ. Defects in the gene encoding TGFβ RI are the cause of aortic aneurysm familial thoracic type 5 (AAT5), Loeys-Dietz syndrome type 2A (LDS2A) and Loeys-Dietz syndrome type 1A (LDS1A).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
May I have a sample of it? I tried several Ab's none of them worked. I just want to test if it works and later order it.
Asked by: Bita
Thank you for your question. We do not offer this antibody, TGFβ RI (RM0016-3A11): sc-101574, in a sample size. The antibody is warrantied for one year for our recommended applications and species. If you choose the purchase the antibody and it does not perform for you as expected, please contact our Technical Service Department and we are happy to help you troubleshoot the antibody, and provide a complimentary replacement antibody or refund of your purchase if necessary.
Answered by: Technical Support
Date published: 2017-09-27
I need to use an antibody to detect the protein in samples of equine origin. Do you know if this mouse monoclonal antibody will work?
Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Rated 1 out of
TGFβ RI Antibody (RM0016-3A11) - Didn't work.Unfortunately the trial sample did not work on human cells (with knock-down controls) compared to an alternate validated TGFBR1 antibody.
Date published: 2018-01-22
Rated 1 out of
TGFβ RI Antibody (RM0016-3A11) reviewI used whole heart homogenates of hypetrophic hearts, hoping I could see an increase of TGFβ RI. This antibody give you several non specific bands.
Date published: 2017-12-05
Rated 5 out of
Strong and cleanWorks in Western blot with mouse primary mammary gland tissue, there is a clear band. 1:500 dilution is sufficient.
Date published: 2017-02-11
Rated 5 out of
ExcellentThis antibody was used to evaluate the role of miR-200b expression in the proliferation of human Tenon's capsule fibroblasts (HTFs) induced by transforming growth factor-beta 1
Date published: 2017-01-20
Rated 4 out of
Good data obtained by IHC using human colonGood data obtained by IHC using human colon adenocarcinoma tissue. -SCBT Publication Review
Date published: 2015-02-15
Rated 4 out of
Publishable data obtained by WB using mousePublishable data obtained by WB using mouse primary mammary gland tissue. -SCBT Publication Review