TBC1D8 抗体 (SS-18): sc-100872

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D8 (TBC1 domain family member 8), also known as VRP (Vascular Rab-GAP/TBC-containing protein), AD3 or HBLP1, is an 897 amino acid protein that is thought to function as a GTPase-activator for Rab proteins. TBC1D8 contains one GRAM domain and one Rab-GAP TBC domain, the latter of which is a highly conserved 200 amino acid motif that conveys the catalytic activity of GTPase-activating proteins. The gene encoding TBC1D8 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.