TAO2 抗体 (L-30): sc-100444

Several mammalian kinases have been identified with sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20. Ste20 is involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MEK kinase. Thousand and one amino acid protein 2 (TAO2), also designated prostate-derived Ste20-like kinase 1 (PSK1) or kinase from chicken homolog C (KFC-C), belongs to the Ste20 subfamily of the Ser/Thr protein kinase family. TAO2 acts as an activator of the JNK MAP kinase pathway through the specific activation of MKK3 and MKK6 kinases. It is a multi-pass membrane protein detected in cytoplasmic vesicle membranes. TAO2 is ubiquitously expressed with highest levels found in brain and testis.