TAF II p55 抗体 (SQ-8): sc-101167

TAF II p55 Antibody (SQ-8) is an IgG_2a κ mouse monoclonal TAF II p55 antibody (also designated TAF II p55 antibody) that detects the TAF II p55 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. TAF II p55 Antibody (SQ-8) is available as the non-conjugated anti-TAF II p55 antibody. TFIID is a general transcription factor that facilitates the preinitiation complex assembly through direct interactions with the TATA promoter element. A multisubunit complex, TFIID consists of a small TATA-binding polypeptide and several TBP-associated factors (TAFs). TAF II p55 (Transcription initiation factor TFIID 55 kDa subunit), also known as TAF7, TAF2F or TAFII55, is a ubiquitously expressed 349 amino acid component of the TFIID complex. Localized to the nucleus, TAF II p55 interacts directly with the largest subunit of the TFIID complex (TAF II p250), as well as with multiple proteins involved in transcriptional activation. Through these interactions, TAF II p55 inhibits the acetyltransferase activity of its binding partners (such as TAF II p250), thereby suppressing their abiltity to stimulate transcription. TAF II p55 is, therefore, thought to act as a checkpoint regulator that delays transcription until the preinitiation complex is fully assembled.

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References:

1. The intronless and TATA-less human TAF(II)55 gene contains a functional initiator and a downstream promoter element.  |  Zhou, T. and Chiang, CM. 2001. J Biol Chem. 276: 25503-11. PMID: 11340078
2. TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.  |  Gegonne, A., et al. 2001. Proc Natl Acad Sci U S A. 98: 12432-7. PMID: 11592977
3. TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.  |  Munz, C., et al. 2003. J Biol Chem. 278: 21510-6. PMID: 12676957
4. TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis.  |  Fukuchi, J., et al. 2004. J Biol Chem. 279: 29921-9. PMID: 15078871
5. TAF7: a possible transcription initiation check-point regulator.  |  Gegonne, A., et al. 2006. Proc Natl Acad Sci U S A. 103: 602-7. PMID: 16407123
6. Presence of the anti-leukemic nucleotide analog, 2-chloro-2′-deoxyadenosine-5′-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP).  |  Hartman, WR., et al. 2007. Arch Biochem Biophys. 459: 223-32. PMID: 17320040
7. Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes.  |  Sedivá, A., et al. 2007. J Clin Immunol. 27: 640-6. PMID: 17851739
8. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators.  |  Chiang, CM. and Roeder, RG. 1995. Science. 267: 531-6. PMID: 7824954
9. Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein.  |  Lavigne, AC., et al. 1996. J Biol Chem. 271: 19774-80. PMID: 8702684