Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Synoviolin Antibody (4H4) is a high quality monoclonal Synoviolin antibody (also designated Synoviolin antibody) suitable for the detection of the Synoviolin protein of mouse, rat and human origin. Synoviolin Antibody (4H4) is available as the non-conjugated anti-Synoviolin antibody. Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Synoviolin, also known as SYVN1 (synovial apoptosis inhibitor 1) or HRD1, is a 617 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-type zinc finger. Expressed ubiquitously with highest expression in kidney and liver, Synoviolin exists as a homodimer that exhibits E3 ubiquitin-protein ligase activity and is a component of the ER-associated degradation (ERAD) complex, a multi-protein structure that mediates the degradation of misfolded proteins within the ER. Synoviolin is upregulated in patients with rheumatoid arthritis (RA), suggesting a role for Synoviolin in the pathogenesis of RA.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.