Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Symplekin, also known as SYMPK, SPK or SYM, is a regulatory protein that localizes to the nucleus, cytoplasm, cytoskeleton and cell junction. Expressed in a variety of tissues including testis, pancreas, stomach, liver and fetal brain, symplekin functions to mediate polyadenylation events and promote gene expression. Symplekin is thought to form a high molecular weight complex (called the tight junction complex) with proteins that are involved in polyadenylation and, once in this complex, may serve as a scaffold that recruits regulatory proteins to polyadenylation sites. In addition, symplekin functions independently and plays a role in the 3'-end maturation of histone mRNAs. Defects in the gene encoding symplekin are associated with hepatocellular carcinoma, suggesting a possible role for symplekin in tumor formation. Symplekin is expressed as two isoforms due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-101128: symplekin (YI-9) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: Randy McDonald
Thank you for your question. Yes, sc-101128: symplekin (YI-9) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: