SUMF2 抗体 (SJ-5): sc-100728

Sulfatases are enzymes that remove sulfate residues from a variety of substrates via the hydrolysis of sulfate esters. In order to function properly, sulfatases require the presence of Cα-formylglycine (FGly), a unique amino acid, in their active site. This amino acid is synthesized by enzymes that use a cysteine to posttranslationally generate FGly. SUMF2 (Sulfatase-modifying factor 2), also known as pFGE or PSEC0171, is a 301 amino acid protein that belongs to the sulfatase-modifying factor family and is expressed in lung, heart, placenta, brain, liver, pancreas, skeletal muscle and kidney. Localized to the lumen of the endoplasmic reticulum (ER), SUMF2 acts as an FGly-generating enzyme that, when functioning alone, has low catalytic activity. When present in a heterodimer with SUMF1 (another FGly-generating protein), SUMF2 exhibits higher rates of catalysis. Four isoforms of SUMF2 are expressed due to alternative splicing events.