SPATA2 抗体 (EE-31): sc-100946

SPATA2 (spermatogenesis associated protein 2), also known as PD1 or tamo, is a 520 amino acid nuclear protein expressed at high levels in testis and at lower levels in various other tissues. SPATA2 is predominantly expressed in Sertoli cells and, although not found in spermatogenic cells, is believed to participate in the regulation of spermatogenesis. SPATA2 shares high sequence identity with the rat homolog (approximately 85%), suggesting that SPATA2 has been conserved through mammalian evolution. In response to FSH (follicle stimulating hormone) stimulation, the primary hormone regulating Sertoli cell function, SPATA2 mRNA levels exhibit a significant increase. This suggests that SPATA2 is an FSH-responsive protein and may play a role in the FSH-dependent function of Sertoli cells.