Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Smurf1 Antibody (45-K) is a high quality monoclonal Smurf1 antibody (also designated SMAD Specific E3 Ubiquitin Protein Ligase 1 antibody, HECT-Type E3 Ubiquitin Transferase SMURF1 antibody, E3 Ubiquitin-Protein Ligase SMURF1 antibody, HSMURF1 antibody, SMAD-Specific E3 Ubiquitin-Protein Ligase 1 antibody, or SMAD Ubiquitination Regulatory Factor 1 antibody) suitable for the detection of the Smurf1 protein of mouse, rat and human origin. Smurf1 Antibody (45-K) is available as the non-conjugated anti-Smurf1 antibody. Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.