SMARCD3 抗体 (RN-18): sc-101163

SMARCD3 Antibody (RN-18) is an IgG_2a κ mouse monoclonal SMARCD3 antibody (also designated SMARCD3 antibody) that detects the SMARCD3 protein of mouse, rat and human origin by WB, IP, IF and ELISA. SMARCD3 Antibody (RN-18) is available as the non-conjugated anti-SMARCD3 antibody. SMARCD3 (SWI/SNF related, matrix associated, Actin dependent regulator of chromatin, subfamily d, member 3), also known as Rsc6p, CRACD3 or BAF60C (BRG1-associated factor 60C), is a member of the SMARCD family and contains one SWIB domain. Two isoforms, isoform 1 and isoform 2 exist due to alternative splicing events. Both isoforms are expressed in placenta, salivary gland, kidney, brain, trachea, uterus, prostate, testis, thyroid, spleen and heart, while isoform 1 is also expressed in adipose tissue and skeletal muscle. Localizing to the nucleus, SMARCD3 is a component of the ATP-dependent chromatin remodeling complex SNF/SWI and is believed to play a role in nucleosome remodeling. SMARCD3 also plays an important role in the regulation of muscle development. In mice, the silencing of the gene en-coding SMARCD3 leads to defects in heart morphogenesis. In addition, both isoforms of SMARCD3 directly interact with and function as coactivators for several transcription factors.

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References:

1. Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.  |  Debril, MB., et al. 2004. J Biol Chem. 279: 16677-86. PMID: 14701856
2. Gene expression profiling and identification of novel prognostic marker genes in neuroblastoma.  |  Takita, J., et al. 2004. Genes Chromosomes Cancer. 40: 120-32. PMID: 15101045
3. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.  |  Lickert, H., et al. 2004. Nature. 432: 107-12. PMID: 15525990
4. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.  |  Takeuchi, JK., et al. 2007. Proc Natl Acad Sci U S A. 104: 846-51. PMID: 17210915
5. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.  |  Flajollet, S., et al. 2007. Mol Cell Endocrinol. 270: 23-32. PMID: 17363140
6. Smarcd3 regulates the timing of zebrafish myogenesis onset.  |  Ochi, H., et al. 2008. J Biol Chem. 283: 3529-3536. PMID: 18056260
7. Diversity and specialization of mammalian SWI/SNF complexes.  |  Wang, W., et al. 1996. Genes Dev. 10: 2117-30. PMID: 8804307
8. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.  |  Ring, HZ., et al. 1998. Genomics. 51: 140-3. PMID: 9693044