Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Sir3 Antibody (184C) is an IgG1 mouse monoclonal Sir3 antibody (also designated Sir3 antibody) suitable for the detection of the Sir3 protein of S. cerevisiae origin by WB and ELISA. Sir3 Antibody (184C) is available as the non-conjugated anti-Sir3 antibody. Telomeric DNA is bound by the transcription regulator Rap1 (repressor activator protein 1, also designated Grf1). In addition to playing a role in silencing the HM mating-type loci, Rap1 is involved in the repression of genes located adjacent to the telomeres, a phenomenon known as telomere position effect (TPE). The silent information regulator proteins Sir2 (also designated Mar1), Sir3 (also designated Mar2, Ste8 or Cmt1) and SIR4 (also designated Ste9, Asd1 or Uth2) form a complex with Rap1. These proteins are essential for TPE silencing and HM structure. Sir1 is essential for silencing the HM mating-type loci, but it has no effect on Tpe. Tel1, a member of the PI 3-kinase family and a homolog of the human ataxia telangiectasia protein, is involved in controlling telomere length. Hdf1 (also referred to as Ku-70), a homolog of the mammalian Ku-70, also plays a role in maintaining telomere length.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.