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Set1 Antibody (1.4) is a high quality monoclonal Set1 antibody (also designated Set1 antibody) suitable for the detection of the Set1 protein of Saccharomyces cerevisiae origin. Set1 Antibody (1.4) is available as both the non-conjugated anti-Set1 antibody form, as well as multiple conjugated forms of anti-Set1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The trithorax gene family functions to maintain specific patterns of gene expression throughout cellular development by activating or repressing transcription. Members of this family contain a highly conserved 130- to 140-amino acid motif designated the SET domain, and include the Drosophila and human trithorax and Su(var)3-9 protein homologues. The Saccharyomyces cerevisiae trithorax homolog Set1, a histone H3-lysine 4 (H3-K4) methylase, regulates chromatin structure, DNA repair, and telomeric function. It also regulates rDNA silencing, either directly or indirectly, via H3 methylation. Set1 forms a complex with six other nonessential proteins. This complex, designated COMPASS (Complex Proteins Associated with Set1) includes Cps25, Cps30, Cps35, Cps40, Cps50, and Cps60. Phosphorylation of the C-terminal domain (CTD) of Pol II at serine 5 by the TFIIH-associated kinase mediates the transition between initiation and elongation. Set1 associates with this phosphorylated form of Poll II, and may provide a molecular memory of recent transcriptional activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can this antibody detect Set mutants which have single point mutation in 470-1080？
Asked by: z2333
Thank you for your question. The exact epitope, between amino acids 470-1080 of Set1 of Saccaromyces cerevisia origin, has not been determined for this monoclonal antibody. Therefore, we could not predict if the antibody would work for your intended application.
Answered by: Technical Support
Date published: 2018-12-11
What is the recommended secondary reagent to be used with sc-101858: Set1 (1.4) mouse monoclonal primary?
Asked by: Cweed
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: