SENP6 抗体 (79-M): sc-100585

SENP6 Antibody (79-M) is an IgG_2a κ mouse monoclonal SENP6 antibody suitable for the detection of the SENP6 protein of human origin by WB, IP, IF, IHC(P) and ELISA. SENP6 Antibody (79-M) is available as the non-conjugated anti-SENP6 antibody. SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins, including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the "GG" region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.

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References:

1. Differential regulation of sentrinized proteins by a novel sentrin-specific protease.  |  Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs.  |  Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
3. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.  |  Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
4. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.  |  Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
5. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.  |  Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.  |  Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
7. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.  |  Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
8. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.  |  Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
9. The SUMO-specific protease SENP5 is required for cell division.  |  Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315