SAV1 抗体 (JJ-6): sc-101205

SAV1 (Salvador homolog 1), also known as SAV, WW45 (45 kDa WW domain protein) or WWP4, is a ubiquitously expressed protein with one SARAH (Salvador/Rassf/Hippo) domain and two WW domains. The SARAH domain is a protein-protein interaction domain that is involved in cell cycle regulation and apoptosis. SAV1 can form homodimers and is believed to function as a scaffold protein of the Hippo pathway. Via its SARAH domain, SAV1 is capable of binding Krs-2, a protein that restricts cell proliferation and promotes apoptosis. This interaction is important for the transduction of apoptosis and cell cycle arrest signals. More specifically, SAV1 is essential for the nuclear translocation and activation of Krs-2. Both of these events (Krs-2 translocation and activation) are required for the subsequent phosphorylation of LATS1 and kpm, two major tumor suppressors. Defects in this pathway (the Hippo pathway) have been associated with tumorigenesis, suggesting that dysfunctional SAV1 may contribute to tumor development.