Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
SAV1 (Salvador homolog 1), also known as SAV, WW45 (45 kDa WW domain protein) or WWP4, is a ubiquitously expressed protein with one SARAH (Salvador/Rassf/Hippo) domain and two WW domains. The SARAH domain is a protein-protein interaction domain that is involved in cell cycle regulation and apoptosis. SAV1 can form homodimers and is believed to function as a scaffold protein of the Hippo pathway. Via its SARAH domain, SAV1 is capable of binding Krs-2, a protein that restricts cell proliferation and promotes apoptosis. This interaction is important for the transduction of apoptosis and cell cycle arrest signals. More specifically, SAV1 is essential for the nuclear translocation and activation of Krs-2. Both of these events (Krs-2 translocation and activation) are required for the subsequent phosphorylation of LATS1 and kpm, two major tumor suppressors. Defects in this pathway (the Hippo pathway) have been associated with tumorigenesis, suggesting that dysfunctional SAV1 may contribute to tumor development.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I am using SAV1 (JJ-6): sc-101205 for immunofluorescence, what dilution of this antibody should I use?
Asked by: Professor Griffin
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: