Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
saposin Antibody (F-15) is a high quality monoclonal saposin antibody (also designated sphingolipid activator protein-1 antibody, SAP1 antibody, sphingolipid activator protein-2 antibody, SAP2 antibody, variant Gaucher disease and variant metachromatic leukodystrophy antibody, prosaposin antibody, PSAP antibody, or Cerebroside sulfate activator antibody) suitable for the detection of the saposin protein of human origin. saposin Antibody (F-15) is available as the non-conjugated anti-saposin antibody. The saposin family includes four structurally related activator proteins, saposin A, B, C and D, that are cleaved from the single precursor protein prosaposin. The gene encoding human prosaposin maps to chromosome 10. Prosaposin is synthesized as a protein that is posttranslationally modified to a shorter form and then further glycosylated to yield a secretory product. This form subsequently undergoes partial proteolysis to produce saposin A, B, C and D. Each saposin family member acts in conjunction with hydrolase enzymes to facilitate the breakdown of glycosphingolipids within the lysosome. The saposins modify the environment of target lipids to make them accessible to the active sites of specific enzymes. Saposin A and C are involved in the hydrolysis of glucosylceramidase, and defects in saposin C are linked to Gaucher′s disease. Saposin B facilitates the hydrolysis of the sulfate group from cerebroside sulfate, and defects in this protein are responsible for a form of metachromatic leukodystropy, a progressive neurodegenerative condition. Saposin D may stimulate the hydrolysis of sphingomyelin and ceramide, but its exact physiological role is not clear.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-100584: saposin (F-15) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: AbPolly
Thank you for your question. Yes, sc-100584: saposin (F-15) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: