Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Sak Antibody (19-Y7) is a high quality monoclonal Sak antibody (also designated Sak antibody) suitable for the detection of the Sak protein of human origin. Sak Antibody (19-Y7) is available as the non-conjugated anti-Sak antibody. The Plk (polo-like kinase) family consists of serine/threonine kinases that are closely related to polo and CDC5 proteins, which are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo-like kinases, which include Plk, Snk (serum-inducible kinase, also designated Plk2), Fnk (FGF-inducible kinase, also designated Plk3 or PRK) and Sak (also designated Plk4), all play a role in cell proliferation. Sak differs from other polo-like kinases because it has only a single polo box, which forms a dimer fold that resides in the nucleolus, centrosomes, and the cleavage furrow. Sak expression slowly increases during S through M phase, and Sak mediates late mitotic progression, cell survival, and postgastrulation embryonic development. APC/C destroys Sak by proteolysis. Reduced Sak expression causes increased incidence of apoptosis and anaphase arrest, while haploinsufficiency of the Sak gene causes spontaneous tumors to develop, primarily in the liver.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with Sak (19-Y7): sc-100413 antibody?
Asked by: TinTin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.