Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Differentiation is a fundamental attribute of multicellular organisms that is required for their body formation. Commitment to differentiation is regulated by a variety of signals and cellular conditions, including availability of differentiation factors, cell-cell contacts and physical and chemial stresses (1-3). In the fission yeast Schizosaccharomyces pombe, the nrd1 gene encoding an RNA binding protein negatively regulates the onset of differentiation. The mammalian homologue of nrd1 is ROD1, which encodes a protein with four repeats of typical RNA binding domains. When expressed in fission yeast, the ROD1 protein functions similar to nrd1. ROD1 is highly expressed in adult and embryo hematopoietic cells or organs. Overexpression of ROD1 effectively blocks the differentiation of human leukemia cells without affecting their proliferative ability, suggesting that ROD1 plays a critical role in controlling differentiation in mammalian cells (3-4).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.