Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The RNase HII complex is an endonuclease that degrades RNA found in RNA:DNA duplexes and is composed of one catalytic subunit and two non-catalytic subunits. RNase HII-A, also called RNASEH2A (Ribonuclease H2 subunit A), RNASEHI, AGS4 or RNHIA, is the 299 amino acid catalytic subunit of RNase HII. Localized to the nucleus, RNase HII-A mediates the removal of Okazaki fragment RNA primers that are present on the lagging strand during DNA replication. RNase HII-A catalyzes the endonucleolytic cleavage of RNA to a 5'-phosphomonoester and is able to bind magnesium or manganese as cofactors. Defects in the gene encoding RNase HII-A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4), an autosomal recessive encephalopathy characterized by cerebral atrophy, leukodystrophy, intracranial calcifications and chronic cerebrospinal fluid (CSF) lymphocytosis. Patients affected by AGS4 have severe neurological dysfunctions and often die in early childhood.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.