RLIM 抗体 (SK-46): sc-101117

RLIM Antibody (SK-46) is an IgG_2a κ mouse monoclonal RLIM antibody (also designated RLIM antibody) that detects the RLIM protein of human origin by WB, IP, IF and ELISA. RLIM Antibody (SK-46) is available as the non-conjugated anti-RLIM antibody. RLIM (RING finger LIM domain-binding protein), also known as RNF12 (RING finger protein 12) or NY-REN-43, is a 624 amino acid RING-H2 zinc finger protein that is involved in protein ubiquitinylation and subsequent degradation. Expressed in a variety of tissues, RLIM binds to the LIM domain of various proteins and functions as a protein ligase that negatively co-regulates LIM homeodomain (LIM-HD) transcription factors. Through its interaction with Sin3A, a component of the histone deacetylase corepressor complex, RLIM is able to recruit the corepressor complex to LIM-HD proteins, thereby inhibiting LIM-HD transcription. In addition to recruiting the deacetylase complex to LIM-HD proteins, RLIM is able to bind to, ubiquinate and subsequently degrade CLIM proteins, which function as positive co-regulators of LIM-HD transcription factors. RLIM contains one RING-type zinc finger and is implicated in renal cell carcinoma.

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References:

1. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.  |  Bach, I., et al. 1999. Nat Genet. 22: 394-9. PMID: 10431247
2. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors.  |  Ostendorff, HP., et al. 2000. Genomics. 69: 120-30. PMID: 11013082
3. Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions.  |  Hiratani, I., et al. 2003. Development. 130: 4161-75. PMID: 12874135
4. Dynamic expression of LIM cofactors in the developing mouse neural tube.  |  Ostendorff, HP., et al. 2006. Dev Dyn. 235: 786-91. PMID: 16395690
5. Localization of mRNAs for Rlim-1, the rat Xlim-1 homolog, in the developing rat brain.  |  Furuyama, T., et al. 1996. Brain Res Mol Brain Res. 36: 152-6. PMID: 9011751