Rev-erbβ 抗体 (QK-6): sc-100911

Orphan nuclear receptors NR1D1 and NR1D2 are more commonly designated Rev-erbα and Rev-erbβ, respectively. Rev-erbα acts as a receptor for triiodothyronine and is composed of three domains: a modulating N-terminal domain, a C-terminal steroid binding domain and a DNA-binding domain. Rev-erbβ binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a competitive repressor of RORα function. It interacts with NCOA5 co-activator which leads to an increase in transcription. Both Rev-erbα and Rev-erbβ are nuclear proteins belonging to the nuclear hormone receptor family of proteins.