RDHE2 抗体 (36-N): sc-100591

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- RDHE2 抗体 36-N 是小鼠单克隆 IgG_2b (kappa轻链)，RDHE2抗体，规格为100 µg/ml
- 免疫human物种的重组RDHE2
- 推荐用于 mouse, rat 和 human 来源的RDHE2 WB, IP 和 ELISA检测
- 目前，我们还没有完成RDHE2 抗体 (36-N)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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此外 RDH 抗体包括 RDH13, RDH11, RDH5, RDHE2和 RDH10
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RDHE2 Antibody (36-N) - Western Blotting - Image 33964

RDHE2 Antibody (36-N) - Western Blotting - Image 35057

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RDHE2 Antibody (36-N) is an IgG_2b κ mouse monoclonal RDHE2 antibody (also designated RDHE2 antibody) that detects the RDHE2 protein of mouse, rat and human origin by WB, IP and ELISA. RDHE2 Antibody (36-N) is available as the non-conjugated anti-RDHE2 antibody. RDHE2 (epidermal retinal dehydrogenase 2), also known as EPHD-2 or retSDR2 (retinal short chain dehydrogenase reductase 2), is a member of the short-chain dehydrogenase/reductase (SDR) family of enzymes that catalyze the first step in the generation of retinaldehyde from retinol. Expressed ubiquitously at low levels with predominant expression in fetal and adult lung, fetal kidney and fetal skin, RDHE2 localizes to the membrane and is a multi-pass membrane protein. RDHE2 contains three motifs that are conserved in most of the SDR family members: a TGXXXGXG motif, a YXXXK motif (the active-site) and an LXNNAG motif. This implies that, similar to other SDR family members, RDHE2 may be involved in the retinol metabolism pathway. In addition, RDHE2 may play a role in the pathogenesis of psoriasis vulgaris, a chronic inflammatory skin disease. This is suggested by the significant upregulation of RDHE2 mRNA levels in the affected skin of psoriasis patients.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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References:

Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. | Matsuzaka, Y., et al. 2002. Biochem Biophys Res Commun. 297: 1171-80. PMID: 12372410
Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. | Markova, NG., et al. 2003. Mol Genet Metab. 78: 119-35. PMID: 12618084
17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. | Chai, Z., et al. 2003. Endocrinology. 144: 2084-91. PMID: 12697717
hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. | Matsuzaka, Y., et al. 2004. Mamm Genome. 15: 668-75. PMID: 15457346

种属	基因名称	基因ID	染色质位置	亚型（mRNA）即位号码	蛋白质即位号码	OMIM™ 号码
Human	SDR16C5	Entrez Gene ID: 195814	8q12.1	XM_011517479, NM_001318049, NM_001318050, NM_138969	UniProt ID: Q8N3Y7	608989
Mouse	Sdr16c5	Entrez Gene ID: 242285	4 A1	NM_181989	UniProt ID: Q7TQA3	N/A

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For Western Blot, is it recommended to use denatured or non-denatured conditions with RDHE2 (36-N): sc-100591 antibody?

Asked by: jenniferc

Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.

Answered by: Technical Support

Date published: 2017-03-27

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RDHE2 抗体 (36-N): sc-100591

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For Western Blot, is it recommended to use denatured or non-denatured conditions with RDHE2 (36-N): sc-100591 antibody?