RDH11 抗体 (EE-12): sc-100588

RDH11 is a member of the short chain retinol dehydrogenase/reductase family that acts as an oxidoreductive catalyst towards retinoids. Expressed in a wide variety of tissues including the liver and prostate, RDH11 can reduce both trans- and cis-retinaldehydes, as well as oxidize trans-retinols. RDH11 prefers NADP+ as a cofactor and, although it has both oxidative and reductive capabilities, it is more efficient in the reductive direction. In the retinal pigment epithelium, RDH11 completes the final step in the retinoid cycle of pigment regeneration by catalyzing the oxidation of 11-cis-retinol to 11-cis retinal. No diseases are currently related to mutations in the gene encoding RDH11.