Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RAMP1 Antibody (3B9) is a high quality monoclonal RAMP1 antibody suitable for the detection of the RAMP1 protein of human origin. RAMP1 Antibody (3B9) is available as the non-conjugated anti-RAMP1 antibody. Receptor activity-modifying proteins (RAMPs) are transmembrane accessory proteins that influence the pharmacological profiles of the calcitonin receptor-like receptors (CRLR). RAMPs associate with CRLR in the endoplasmic reticulum and facilitate the glycosylation and transport of CRLR to the cell surface, where the mature protein then operates as a receptor for two structurally related vasodilatory peptides, calcitonin-gene-related peptide (CGRP) or adrenomedullin (ADM). RAMP1 associating with CRLR confers a CGRP receptor, while RAMP-2 and RAMP-3 preferentially induce a responsiveness to ADM. RAMP proteins, including RAMP1, RAMP-2 and RAMP-3, are structurally similar as they are type I receptors, which have a single extracellular N-terminus and a cytoplasmic C-terminus, and they share approximately 55% sequence similarity. RAMP1 expression is highest in the uterus, brain and gastrointestinal tract, whereas RAMP-2 and RAMP-3 are highest in lung, breast and fetal tissues.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
does RAMP1 Antibody (3B9) antibody recognize the extracellular domain of the receptor? in other words, would it in principle work on unfixed cells by facs?
Asked by: neuroimmune84
Thank you for your question. Yes, this antibody is raised against the extracellular domain of RAMP1. We have not tested the antibody by FACS so we do not know if it would be suitable for this application.
Answered by: Technical Support
Date published: 2019-04-13
For Western Blot, is it recommended to use denatured or non-denatured conditions with RAMP1 (3B9): sc-293438 antibody?
Asked by: Dr Ninau Qelp
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.