Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PSMC3 Antibody (28-K) is a high quality monoclonal PSMC3 antibody (also designated PSMC3 antibody) suitable for the detection of the PSMC3 protein of mouse, rat and human origin. PSMC3 Antibody (28-K) is available as the non-conjugated anti-PSMC3 antibody. In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex, and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. PSMC3 (Proteasome 26S subunit ATPase 3), also known as TBP1 (Tat-binding protein 1), is a 439 amino acid member of the AAA ATPase family. Localized to both the nucleus and the cytoplasm, PSMC3 functions as a subunit of the 19S regulatory complex and is involved in regulating the substrate specificity of the 26S Proteasome. Additionally, PSMC3 interacts with the HIV protein HIV-1 Tat and, via this interaction, mediates the association of the viral protein with transcription complexes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with PSMC3 (28-K): sc-100462 antibody?
Asked by: Germaine
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.