Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PSF Antibody (39-1) is a high quality monoclonal PSF antibody (also designated Splicing Factor Proline And Glutamine Rich antibody, PSF antibody, Polypyrimidine Tract Binding Protein Associated antibody, Protein Phosphatase 1 Regulatory Subunit 140 antibody, DNA-Binding P52/P100 Complex 100 KDa Subunit antibody, Splicing Factor Proline- And Glutamine-Rich antibody, PPP1R140 antibody, Polypyrimidine Tract-Binding Protein-Associated Splicing Factor antibody, or PTB-Associated-Splicing Factor antibody) suitable for the detection of the PSF protein of mouse, rat and human origin. PSF Antibody (39-1) is available as the non-conjugated anti-PSF antibody. Pre-mRNA splicing is a critical step in the post-translational regulation of gene expression. The process of removing intron sequences from mRNA is a two-step enzymatic reaction that requires the action of the spliceosome, a large multicomponent ribonucleoprotein complex. The polypyrimidine tract-binding protein (PTB)-associated splicing factor (PSF) is a ubiquitously expressed protein that forms a complex with PTB, also designated hnRNP I, which is required for early spliceosome formation and is essential for catalytic step II. The PSF protein contains two RNA recognition motifs (RRMs), a proline- and glutamine-rich amino terminal domain, and two carboxy-terminal nuclear localization signals. PSF is localized to the nucleus in punctate structures called speckles, which are absent from nucleoli. The localization of PSF to speckles is dependent upon the presence of the second RRM motif. PSF also can associate with the DNA binding domains (DBDs) of thyroid hormone receptors and retinoic acid receptors, where it acts as a repressor by recruiting HDACs to the DBDs. PSF is expressed in neurons during development and may be involved in neuronal differentiation and maturation. PSF is proteolytically cleaved to produce a shorter fragment in myeloid cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.