PPIL1 抗体 (LB-72): sc-100701

PPIL1 Antibody (LB-72) is an IgG_2a κ mouse monoclonal PPIL1 antibody (also designated PPIL1 antibody) that detects the PPIL1 protein of mouse, rat and human origin by WB, IP and ELISA. PPIL1 Antibody (LB-72) is available as the non-conjugated anti-PPIL1 antibody. PPIL1 (peptidylprolyl isomerase (cyclophilin)-like 1), also known as CYPL1, PPIase, CGI-124 or hCyPX, is a member of the cyclophilin-type PPIase family of proteins. PPIL1 contains one PPIase cyclophilin-type domain and is ubiquitously expressed with predominant expression in skeletal muscle and heart. PPIL1 is a component of the 35 S U5 snRNP (small nuclear ribonucleoprotein) and is also recruited to the 45 S activated spliceosome by Skip (SNW1), a transcriptional coactivator. PPIL1 stably associates with Skip and may play a role in spliceosome activation, possibly functioning as a foldase or a molecular chaperone. In addition, PPIL1 interacts with Op18, a protein involved in microtubule stabilization, and may participate in cell proliferation. PPIL1 expression levels are elevated in cancer cells, further supporting a role for PPIL1 in proliferation and tumorigenesis.

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References:

1. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization.  |  Mann, SS., et al. 1998. Cytogenet Cell Genet. 83: 228-9. PMID: 10072585
2. Cyclophilins of a novel subfamily interact with SNW/SKIP coregulator in Dictyostelium discoideum and Schizosaccharomyces pombe.  |  Skruzný, M., et al. 2001. Biochim Biophys Acta. 1521: 146-51. PMID: 11690648
3. Transcriptional coregulator SNW/SKIP: the concealed tie of dissimilar pathways.  |  Folk, P., et al. 2004. Cell Mol Life Sci. 61: 629-40. PMID: 15052407
4. Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells.  |  Obama, K., et al. 2006. Clin Cancer Res. 12: 70-6. PMID: 16397026
5. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP.  |  Xu, C., et al. 2006. J Biol Chem. 281: 15900-8. PMID: 16595688
6. Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain.  |  Ozaki, K., et al. 1996. Cytogenet Cell Genet. 72: 242-5. PMID: 8978786