Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Rho, Rac and Cdc42 are members of the small GTPase family. These proteins act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. Activation of these proteins results in rearrangements of filamentous actin and the formation of actin stress fibers. Many of the targets of these GTPases are involved in signal transduction events mediated by Src3 homology (SH3) domains. POSH, for "plenty of SH3s", is a Rac binding protein with four SH3 domains. POSH preferentially interacts with the GTP form of RAC and not with the GDP-bound RAC. Ectopic expression of POSH elicits JNK activation and nuclear translocation of NFkB, suggesting that POSH is involved in Rac regulation of these kinase pathways. Overexpression of POSH has also been shown to induce apoptosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with POSH (YY-5): sc-100815 antibody?
Asked by: TinTin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.