Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine protein phosphatases. POPX1, also designated partner of PIX 1, PPM1E (protein phosphatase 1E) or PP2CH, and POPX2, also designated partner of PIX 2, PPM1F (protein phosphatase 1F), CaMKPase (CaM-kinase phosphatase), or FEM-2, belong to the PP2C family of serine/threonine phosphatases. Members of the PP2C family are negative regulators of cell stress response pathways. POPX2 is a ubiquitously expressed protein and POPX1 is predominantly expressed in brain and testis. POPX1 and POPX2 specifically interact with PIX (PAK interacting exchange factor) proteins and negatively regulate the activity of αPAK, a protein kinase that can lead to the breakdown of actin stress fibers and other morphological changes. POPX2 can also interact with and regulate CaMKII activity. Overexpression of POPX2 can result in caspase-dependent apoptosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with POPX2 (SJ-6): sc-100416 antibody?
Asked by: cjMara
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.