POGK 抗体 (5Q13): sc-100648

POGK (pogo transposable element with KRAB domain), also known as BASS2 or LST003, is a 609 amino acid protein that may be a member of the DNA-mediated transposon family. Localizing to the nucleus, POGK contains an N-terminal KRAB (Kruppel-associated box) domain, an HTH CENP-B-type (helix-turn-helix and centromere protein B-type) DNA-binding domain and a C-terminal DDE domain. The KRAB domain is a potent transcriptional repression motif and is approximately 75 amino acids in length. DDE domains are catalytic motifs consisting of two conserved aspartic acids separated by 70 amino acids and a conserved glutamic acid that is further separated by another 35 amino acids. DDE domains are characteristic of DNA transposases and retroviral integrases.