PLIC-2 抗体 (QR-2): sc-100612

PLIC-2 Antibody (QR-2) is an IgG_2a κ mouse monoclonal PLIC-2 antibody (also designated PLIC-2 antibody) that detects the PLIC-2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. PLIC-2 Antibody (QR-2) is available as the non-conjugated anti-PLIC-2 antibody. Proteins linking integrin-assocated protein with cytoskeleton (PLICs) provide a signaling connection between the membrane receptors for thrombospondin and the cytoskeleton. The PLIC proteins are part of ubiquitin-like proteins, all of which contain an ubiquitin-like domain. Both PLIC-1 and PLIC-2, known also as ubiquilin 1 and ubiquilin 2, associate with proteasomes and two different E3 ubiquitin ligase enzymes. These associations suggest that PLIC-1 and PLIC-2 may link ubiquitination machinery and proteasomes for in vivo protein degradation. PLIC-1 and PLIC-2 both bind to a short peptide within the ATPase domain of the HSP70-like Stch protein. PLIC-1 is a cytoplasmic protein that associates with the DAN gene product and may play a critical role in cell cycle regulation. It also interacts with two proteins linked to early-onset Alzheimer′s disease, presenilin-1 and presenilin-2, and promotes accumulation of the presenilin proteins. PLIC-1 is abundant in neurons of healthy brain, neurofibrillary tangles in Alzheimer′s-diseased brain and Lewy bodies of Parkinson-diseased brain.

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References:

1. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.  |  Wu, AL., et al. 1999. Mol Cell. 4: 619-25. PMID: 10549293
2. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.  |  Kaye, FJ., et al. 2000. FEBS Lett. 467: 348-55. PMID: 10675567
3. Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3.  |  Hanaoka, E., et al. 2000. J Hum Genet. 45: 188-91. PMID: 10807547
4. Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids.  |  Kaye, FJ. and Shows, TB. 2000. Cytogenet Cell Genet. 89: 116-7. PMID: 10894951
5. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.  |  Kleijnen, MF., et al. 2000. Mol Cell. 6: 409-19. PMID: 10983987
6. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.  |  Mah, AL., et al. 2000. J Cell Biol. 151: 847-62. PMID: 11076969
7. Identification of a new cellular protein that can interact specifically with DAN.  |  Ozaki, T., et al. 1997. DNA Cell Biol. 16: 985-91. PMID: 9303440