Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PLIC-2 Antibody (QR-2) is a high quality monoclonal PLIC-2 antibody (also designated PLIC-2 antibody) suitable for the detection of the PLIC-2 protein of mouse, rat and human origin. PLIC-2 Antibody (QR-2) is available as the non-conjugated anti-PLIC-2 antibody. Proteins linking integrin-assocated protein with cytoskeleton (PLICs) provide a signaling connection between the membrane receptors for thrombospondin and the cytoskeleton. The PLIC proteins are part of ubiquitin-like proteins, all of which contain an ubiquitin-like domain. Both PLIC-1 and PLIC-2, known also as ubiquilin 1 and ubiquilin 2, associate with proteasomes and two different E3 ubiquitin ligase enzymes. These associations suggest that PLIC-1 and PLIC-2 may link ubiquitination machinery and proteasomes for in vivo protein degradation. PLIC-1 and PLIC-2 both bind to a short peptide within the ATPase domain of the HSP70-like Stch protein. PLIC-1 is a cytoplasmic protein that associates with the DAN gene product and may play a critical role in cell cycle regulation. It also interacts with two proteins linked to early-onset Alzheimer′s disease, presenilin-1 and presenilin-2, and promotes accumulation of the presenilin proteins. PLIC-1 is abundant in neurons of healthy brain, neurofibrillary tangles in Alzheimer′s-diseased brain and Lewy bodies of Parkinson-diseased brain.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I am using PLIC-2 (QR-2): sc-100612 for immunofluorescence, what dilution of this antibody should I use?
Asked by: DefinitelyNotMatt
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: