PIP5KIII 抗体 (64-Q6): sc-100408

PIP5KIII Antibody (64-Q6) is a high quality monoclonal PIP5KIII antibody (also designated PIP5KIII antibody) suitable for the detection of the PIP5KIII protein of mouse, rat and human origin. PIP5KIII Antibody (64-Q6) is available as the non-conjugated anti-PIP5KIII antibody. Phosphorylation of phosphatidylinositol (PtdIns) derivatives is suggested to play a role in regulating cytoskeletal functions, membrane trafficking and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. PtdIns proteins are distinguished by the degree and position of phosphorylation of the inositol ring. PIP5KIII (Phosphatidylinositol 3-phosphate 5-kinase), also known as PIP5K3, FAB1, CFD, PIKFYVE or ZFYVE29 is 2,098 amino acid protein that synthesizes phosphatidylinositol-3,5-bisphosphate by catalyzing the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the inositol ring. PIP5KIII is thought to play a major role in nuclear migration and the endocytic-vacuolar pathway. PIP5KIII exists as four alternatively spliced isoforms and contains a DEP domain, a FYVE-type zinc finger and a PIPK domain. Defects in the gene encoding PIP5KIII lead to corneal fleck dystrophy (CFD), an autosomal disorder in which small white flecks are found throughout the corneal stroma..