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Labware ships FedEx Ground free of charge to the contiguous US
PICOT, also known as GLRX3 (glutaredoxin 3), GRX3, GRX4, GLRX4, HUSSY-22, TXNL2 or TXNL3, is a 335 amino acid protein that contains one thioredoxin domain and two glutaredoxin domains. Localized to the cytoplasm and the cell cortex, PICOT is thought to play a role in regulating the thioredoxin system and may weakly interact with PKC θ (protein kinase C theta). Through its ability to regulate the thioredoxin pathway, PICOT inhibits cardiac hypertrophy (a thickening of the heart muscle usually caused by high blood pressure) by negatively regulating NFAT (Nuclear factor of activated T-cells) signaling. Although PICOT contains one thioredoxin domain, it lacks the two redox-reactive cysteines that are required for catalytic activity, suggesting that PICOT lacks thioredoxin function. PICOT is expressed in testis, heart and spleen with lower levels detected in thymus, lung, colon, placenta and small intestine.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Do you have any information for chromatin immuno-precipitation assay using this antibody?
Asked by: Pinak
Thank you for your question. We have not tested this antibody for chromatin immunoprecipitation (ChIP), and we are not aware of any publications citing use of the antibody this application at this time.
Answered by: Technical Support
Date published: 2017-07-25
For Western Blot, is it recommended to use denatured or non-denatured conditions with PICOT (JF-6): sc-100601 antibody?
Asked by: cjMara
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
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