PGM 3 抗体 (EC-13): sc-100410

Phosphoglucomutase (PGM), which belongs to the hexose-phosphate mutase family, plays an essential role in glycogen catabolism (glycogenolysis) as well as in the process of glycogen synthesis (glycogenesis). During glycogenolysis, PGM converts glucose-1-phosphate (Glc-1-P) to glucose-6-phosphate (Glc-6-P), thus promoting glycolysis and the pentose phosphate pathway. During glycogenesis, PGM functions in the opposite manner, converting glucose-6-phosphate into glucose-1-phosphate, to facilitate glycogen synthesis. PGM has five structural loci: PGM 1, PGM 2, PGM 3, PGM 4 and Aciculin. These five genetic forms of PGM differ in amino acid sequences but catalyze the same reactions, therefore indicating that they are isozymes. PGM 3 is a 542 amino acid protein expressed ubiquitously with the exception of lung tissue. Highest level of expression is found in heart, liver, pancreas and placenta tissue. All phosphoglucomutases act as monomers and bind one magnesium ion per subunit.