Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Proteins containing PDZ domains play a role in a wide array of biological functions including protein scaffolding, organization of ion channels, and signal transduction. The PDZ domain containing protein PDZK1 interacts with multiple targets, including MAP17 and cMOAT and also NaPi-IIa, which implicates PDZK1 in ion channel formation. PDZK1 localizes to the plasma membrane of epithelial cells, where it is able to interact simultaneously with more than one type of channel, by utilizing its 4 PDZ domains, and thus acts as an adaptor between different cell surface receptors. Furthermore, PDZK1 is markedly upregulated in human carcinomas of epithelial origin, and the cluster formed by its association with cMOAT and MAP17 may potentially play role in multidrug resistance. Therefore, PDZK1 may be a new target for cancers cells resistance to chemotherapeutic agents.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.