Pdcd-7 抗体 (S-18): sc-101250

Pdcd-7 Antibody (S-18) is an IgG_2a κ mouse monoclonal Pdcd-7 antibody (also designated Pdcd-7 antibody) that detects the Pdcd-7 protein of mouse, rat and human origin by WB, IP and ELISA. Pdcd-7 Antibody (S-18) is available as the non-conjugated anti-Pdcd-7 antibody. PD-1 (programmed cell death-1 protein) is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Expression of PD-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. PD-2 (also known as PDCD2, PDL2 or B7DC) is highly expressed in placenta, heart, pancreas, lung and liver. PD-2 is also expressed in spleen, lymph nodes and thymus. Pdcd-4 is a nuclear protein localized to the nucleus of proliferating cells. ALG-2 (apoptosis-linked gene 2), also designated programmed cell death protein 6, is a Ca2+-binding protein that participates in regulatory events occurring late in the apoptotic program and where several death signals converge. Pdcd-7, also designated programmed cell death protein 7, is a 485 amino acid protein that promotes apoptosis when overexpressed. Human Pdcd-7 and the mouse Pdcd-7 protein, designated as Es18, share 95% homology in the overlapping region.

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References:

1. Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.  |  Park, EJ., et al. 1999. Nucleic Acids Res. 27: 1524-30. PMID: 10037816
2. Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.  |  Li, W., et al. 2000. Neuroscience. 96: 161-8. PMID: 10683420
3. PD-L2 is a second ligand for PD-1 and inhibits T cell activation.  |  Latchman, Y., et al. 2001. Nat Immunol. 2: 261-8. PMID: 11224527
4. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.  |  Ishida, Y., et al. 1992. EMBO J. 11: 3887-95. PMID: 1396582
5. Alterations of DNA copy number and expression in genes involved in cell cycle regulation and apoptosis signal pathways in gamma-radiation-sensitive SX9 cells and -resistant SR-1 cells.  |  Koshikawa, T., et al. 2005. Radiat Res. 163: 374-83. PMID: 15799692
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7. Deregulated stress system in non-obese diabetic lymphocyte.  |  Liu, Z. and Aune, TM. 2006. Genes Immun. 7: 352-8. PMID: 16691184
8. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.  |  Agata, Y., et al. 1996. Int Immunol. 8: 765-72. PMID: 8671665